Mitogenicity of influenza hemagglutinin glycoproteins and influenza viruses bearing H2-hemagglutinin
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چکیده
منابع مشابه
Compensatory hemagglutinin mutations alter antigenic properties of influenza viruses.
Influenza viruses routinely acquire mutations in antigenic sites on the globular head of the hemagglutinin (HA) protein. Since these antigenic sites are near the receptor binding pocket of HA, many antigenic mutations simultaneously alter the receptor binding properties of HA. We previously reported that a K165E mutation in the Sa antigenic site of A/Puerto Rico/8/34 (PR8) HA is associated with...
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Since the 1918 influenza A virus (IAV) pandemic, H1N1 viruses have circulated in human populations. The hemagglutinin (HA) of IAV determines viral antigenicity and often undergoes N-linked glycosylation (NLG) at several sites. Interestingly, structural analysis of the 1918 and 2009 H1N1 pandemic viruses revealed antigenic similarities attributable to the conserved epitopes and the NLG statuses ...
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properties of influenza viruses 2 Jaclyn L. Myers, Katherine S. Wetzel, Susanne L. Linderman, Yang Li, Colleen 3 B. Sullivan, Scott E. Hensley 4 5 Wistar Institute, Philadelphia, PA 19104, USA 6 Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA 7 Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA 8 These authors contributed equall...
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Background. Detection of neutralizing antibodies (nAbs) to influenza A virus hemagglutinin (HA) antigens by conventional serological assays is currently the main immune correlate of protection for influenza vaccines However, current prepandemic avian influenza vaccines are poorly immunogenic in inducing nAbs despite considerable protection conferred. Recent studies show that Ab-dependent cell-...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1981
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.34.1.140-143.1981